Mayo Thompson (born 26 February 1944 in Houston, Texas) is an American musician and visual artist best known as the leader of the avant-garde rock band Red Crayola. In 1966, Thompson formed the band Red Crayola with fellow art students Frederick Barthelme (brother of novelist Donald Barthelme) and Steve Cunningham amid the burgeoning Houston psychedelic scene and gathered a "travelling entourage" who improvised with them, known as The Familiar Ugly. Their intended second album, Coconut Hotel was rejected by their record company for being too abstract and experimental.

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